Continuous Bioprocessing

Overview

Manufacturing approach where upstream and downstream operations run in a connected, uninterrupted flow rather than discrete batch cycles, enabling real-time feedback control, higher throughput per unit, and cost-efficient scale-out for distributed manufacturing Continuous downstream processing enables 10-12 chromatography cycles per day versus only 3 cycles per batch in conventional batch mode, which is identified as the key enabler for real-time product quality feedback control across all downstream unit operations. Continuous processing facilitates global manufacturing standardization: real-time data from continuous operations can be centrally monitored to verify that a process runs equivalently across geographically distributed manufacturing sites, enabling scale-out rather than scale-up economics. (Segment 8 (35:00-40:00))