Digital Twins in Bioprocessing

Overview

Computational models of bioprocessing unit operations or whole plants used to simulate process behavior, align development and manufacturing constraints before physical experiments, and provide simple real-time deviation alerts in commercial operations Digital twin models of unit operations or whole plants can help development teams understand manufacturing constraints and acceptable process design space before conducting experiments, reducing the misalignment between development-defined platforms and manufacturing-acceptable processes. Simple mass balance and filter fouling models are immediately practical digital twin implementations — not complex mechanistic chromatography models — that can alert manufacturing operators to process deviations and indicate likely root causes without requiring full mechanistic understanding. (Segment 4 (15:00-20:00))