High-Throughput Experimentation

Overview

Miniaturized automated experimental platforms used in bioprocess development to rapidly characterize large design spaces, reducing timelines for purification development and generating large datasets required for model training High-throughput experimentation combined with process modeling has significantly shortened downstream development timelines over the past five to seven years, addressing the bottleneck created by increasing molecular format diversity requiring non-platform purification strategies for each molecule. The critical-path window for speed in drug development is from DNA construct to first GMP toxicology manufacturing batch, a period of four to six months; high-throughput automation provides the greatest productivity benefit precisely in this window. (Segment 4 (15:00-20:00))