John Maraganore

Overview

Founder of Alnylam Pharmaceuticals who sustained the company through 20+ years of extreme valuation cycles to achieve the first approved siRNA drugs before reaching cash-flow break-even profitability. John Maraganore founded Alnylam Pharmaceuticals and spent over 20 years before the first drug approval, then another 7 years before reaching cash-flow break-even profitability. Maraganore attributed Alnylam's ability to avoid acquisition to navigating extreme valuation swings — high periods when no one could afford them, and low periods after toxicity setbacks when no one wanted them. (Segment 4 (15:00-20:00))