Coefficient Bio

Overview

Coefficient Bio was a clinical development reasoning AI tool co-founded by Samuel Stanton and Joyce Hong. The company was acquired by Anthropic in early 2026. Its core insight, articulated by Stanton, was that context engineering — not raw model intelligence — was the primary technical challenge in applying AI to scientific judgment tasks. The company focused on context engineering and tool ergonomics to enable rigorous scientific decision-making with large language models.

Dimension Capital was a founding co-investor. Samuel Stanton's background includes a PhD in algorithmic decision-making and work on antibody lab-in-the-loop systems at Genentech Precision Design — grounding Coefficient Bio's approach in both computational rigor and wet-lab reality.